G12.21

Billable

ChapterG00–G99

Ranksubcategory

Official Description

Amyotrophic lateral sclerosis

Metadata & Insights

•2026 ICD-10-CM Edition - Effective October 1, 2025.
•Billable/specific code (valid for reimbursement).
•Chapter 6: Diseases of the Nervous System (G00-G99).

General instructions are available for the parent sections:

View CH6 Notes

Clinical Hierarchy

CH6Diseases of the nervous system (G00-G99)

G10-G14Systemic atrophies primarily affecting the central nervous system (G10-G14)

G12Spinal muscular atrophy and related syndromes

G12.2Motor neuron disease

G12.21Amyotrophic lateral sclerosis

Applicable Ancestor Context

The following parent sections contain instructions or notes that apply to G12.21:

chapterCH6

Diseases of the nervous system (G00-G99)

View context instructions

Alphabetic Index Mentions

These are Diagnosis Index lookup paths that route to G12.21. Use them as entry terms for search, then confirm final coding instructions in the Tabular List and notes above.

13 raw paths

Amyotrophia, amyotrophy, amyotrophic1 unique routes

lateral sclerosis→G12.21

Atrophy, atrophic (of)4 unique routes

Duchenne-Aran→G12.21

muscle, muscular (diffuse) (general) (idiopathic) (primary)(3 variants)

Duchenne-Aran→G12.21

progressive (bulbar)→G12.21

spinal

Aran-Duchenne→G12.21

Disease, diseased1 unique routes

motor neuron (bulbar) (mixed type) (spinal)

amyotrophic lateral sclerosis→G12.21

Duchenne-Aran muscular atrophy1 unique routes

Direct index entry→G12.21

Paralysis, paralytic (complete) (incomplete)3 unique routes

Sclerosis, sclerotic3 unique routes

amyotrophic (lateral)→G12.21

lateral (amyotrophic) (descending) (spinal)→G12.21

spinal (cord) (progressive)

lateral (amyotrophic)→G12.21

MS-DRG Classification

2026 v43.1

This code is grouped within the following Diagnosis Related Group(s) for clinical reimbursement:

DRG 056

Degenerative Nervous System Disorders with MCC

DRG 057

Degenerative Nervous System Disorders without MCC

Cross Reference

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Find surgical and procedural codes related to Amyotrophic lateral sclerosis.

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