Chapter 2

C00–D49: Neoplasms

Neoplasms diagnostic classification updated for 2026.

Internal Codes
  • D42.9

    Neoplasm of uncertain behavior of meninges, unspecified

  • D43.0

    Neoplasm of uncertain behavior of brain, supratentorial

  • D43.1

    Neoplasm of uncertain behavior of brain, infratentorial

  • D43.2

    Neoplasm of uncertain behavior of brain, unspecified

  • D43.3

    Neoplasm of uncertain behavior of cranial nerves

  • D43.4

    Neoplasm of uncertain behavior of spinal cord

  • D43.8

    Neoplasm of uncertain behavior of other specified parts of central nervous system

  • D43.9

    Neoplasm of uncertain behavior of central nervous system, unspecified

  • D44.0

    Neoplasm of uncertain behavior of thyroid gland

  • D44.10

    Neoplasm of uncertain behavior of unspecified adrenal gland

  • D44.11

    Neoplasm of uncertain behavior of right adrenal gland

  • D44.12

    Neoplasm of uncertain behavior of left adrenal gland

  • D44.2

    Neoplasm of uncertain behavior of parathyroid gland

  • D44.3

    Neoplasm of uncertain behavior of pituitary gland

  • D44.4

    Neoplasm of uncertain behavior of craniopharyngeal duct

  • D44.5

    Neoplasm of uncertain behavior of pineal gland

  • D44.6

    Neoplasm of uncertain behavior of carotid body

  • D44.7

    Neoplasm of uncertain behavior of aortic body and other paraganglia

  • D44.9

    Neoplasm of uncertain behavior of unspecified endocrine gland

  • D45

    Polycythemia vera

  • D46.0

    Refractory anemia without ring sideroblasts, so stated

  • D46.1

    Refractory anemia with ring sideroblasts

  • D46.20

    Refractory anemia with excess of blasts, unspecified

  • D46.21

    Refractory anemia with excess of blasts 1

  • D46.22

    Refractory anemia with excess of blasts 2

  • D46.4

    Refractory anemia, unspecified

  • D46.9

    Myelodysplastic syndrome, unspecified

  • D46.A

    Refractory cytopenia with multilineage dysplasia

  • D46.B

    Refractory cytopenia with multilineage dysplasia and ring sideroblasts

  • D46.C

    Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality

  • D46.Z

    Other myelodysplastic syndromes

  • D47.01

    Cutaneous mastocytosis

  • D47.02

    Systemic mastocytosis

  • D47.09

    Other mast cell neoplasms of uncertain behavior

  • D47.1

    Chronic myeloproliferative disease

  • D47.2

    Monoclonal gammopathy

  • D47.3

    Essential (hemorrhagic) thrombocythemia

  • D47.4

    Osteomyelofibrosis

  • D47.9

    Neoplasm of uncertain behavior of lymphoid, hematopoietic and related tissue, unspecified

  • D47.Z1

    Post-transplant lymphoproliferative disorder (PTLD)

  • D47.Z2

    Castleman disease

  • D47.Z9

    Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue

  • D48.0

    Neoplasm of uncertain behavior of bone and articular cartilage

  • D48.110

    Desmoid tumor of head and neck

  • D48.111

    Desmoid tumor of chest wall

  • D48.112

    Desmoid tumor, intrathoracic

  • D48.113

    Desmoid tumor of abdominal wall

  • D48.114

    Desmoid tumor, intraabdominal

  • D48.115

    Desmoid tumor of upper extremity and shoulder girdle

  • D48.116

    Desmoid tumor of lower extremity and pelvic girdle

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