Malignant immunoproliferative diseases and certain other B-cell lymphomas
In Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96), chapter 2: Neoplasms
12 billable codes under C88: 10 are a CC; all map to HCC 21 (Lymphoma and Other Cancers).A CC or MCC (major CC) is a secondary diagnosis that raises the MS-DRG payment. An HCC counts toward a Medicare Advantage patient's risk score.
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Instructional notes
Also applies, from Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96)
These notes sit on C81-C96 and apply to every code under it, including C88.
Official coding guidelines
From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.
Rules for coding benign and malignant neoplasms: using the Neoplasm Table, sequencing primary and secondary sites, treatment encounters, complications, and current cancer versus personal history.
- Admission/Encounter for treatment of primary site (page 33)
- Admission/Encounter for treatment of secondary site (page 33)
- Coding and sequencing of complications (page 34)
- Primary malignancy previously excised (page 34)
- Admissions/Encounters involving antineoplastic chemotherapy, immunotherapy and radiation therapy (page 35)
- Admission/encounter to determine extent of malignancy (page 36)
- Symptoms, signs, and abnormal findings listed in Chapter 18 associated with neoplasms (page 36)
- Admission/encounter for pain control/management (page 36)
All codes under C88
C88 can't be used on a claim. Pick a billable code below; grey headings group them.
- C88.0Waldenström macroglobulinemia
- C88.00Waldenstrom macroglobulinemia not having achieved remission
- C88.01Waldenstrom macroglobulinemia, in remission
- C88.2Heavy chain disease
- C88.20Heavy chain disease not having achieved remission
- C88.21Heavy chain disease, in remission
- C88.3Immunoproliferative small intestinal disease
- C88.30Immunoproliferative small intestinal disease not having achieved remission
- C88.31Immunoproliferative small intestinal disease, in remission
- C88.4Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
- C88.40Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] not having achieved remission
- C88.41Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma], in remission
- C88.8Other malignant immunoproliferative diseases
- C88.80Other malignant immunoproliferative diseases not having achieved remission
- C88.81Other malignant immunoproliferative diseases, in remission
- C88.9Malignant immunoproliferative disease, unspecified
- C88.90Malignant immunoproliferative disease, unspecified not having achieved remission
- C88.91Malignant immunoproliferative disease, unspecified, in remission
C88 MS-DRGs
As the principal diagnosis, the billable codes under C88 group to these 12 MS-DRGs (v44.0). Which one applies depends on procedures performed, secondary diagnoses (CC/MCC), and the patient's age and discharge status.
- DRG 820 Lymphoma and Leukemia with Major O.R. Procedures with MCC (12 of 12 codes)
- DRG 821 Lymphoma and Leukemia with Major O.R. Procedures with CC (12 of 12 codes)
- DRG 822 Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC (12 of 12 codes)
- DRG 823 Lymphoma and Non-Acute Leukemia with Other Procedures with MCC (12 of 12 codes)
- DRG 824 Lymphoma and Non-Acute Leukemia with Other Procedures with CC (12 of 12 codes)
- DRG 825 Lymphoma and Non-Acute Leukemia with Other Procedures without CC/MCC (12 of 12 codes)
- DRG 840 Lymphoma and Non-Acute Leukemia with MCC (12 of 12 codes)
- DRG 841 Lymphoma and Non-Acute Leukemia with CC (12 of 12 codes)
- DRG 842 Lymphoma and Non-Acute Leukemia without CC/MCC (12 of 12 codes)
- DRG 974 HIV with Major Related Condition with MCC (2 of 12 codes)
- DRG 975 HIV with Major Related Condition with CC (2 of 12 codes)
- DRG 976 HIV with Major Related Condition without CC/MCC (2 of 12 codes)
Other codes that refer to C88
Notes on these codes point to C88.
About the condition
Plain-language background from MedlinePlus (National Library of Medicine), not coding guidance.
Lymphoma
Lymphoma is a cancer of a part of the immune system called the lymph system. There are many types of lymphoma. One type is Hodgkin disease. The rest are called non-Hodgkin lymphomas.
Read more about lymphoma on MedlinePlusCode history
Valid since FY2016, when ICD-10-CM took effect on October 1, 2015. No changes since.
