Atypical virus infections of central nervous system
In Viral and prion infections of the central nervous system (A80-A89), chapter 1: Certain Infectious and Parasitic Diseases
10 billable codes under A81: all are a CC; all map to HCC 127 (Dementia, Mild or Unspecified).A CC or MCC (major CC) is a secondary diagnosis that raises the MS-DRG payment. An HCC counts toward a Medicare Advantage patient's risk score.
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Instructional notes
Includes: conditions that are coded here
- diseases of the central nervous system caused by prions
Use additional code: add a second code for this, listed after this one
- code, if applicable, to identify:
- dementia with anxiety (F02.84, F02.A4, F02.B4, F02.C4)
- dementia with behavioral disturbance (F02.81-, F02.A1-, F02.B1-, F02.C1-)
- dementia with mood disturbance (F02.83, F02.A3, F02.B3, F02.C3)
- dementia with psychotic disturbance (F02.82, F02.A2, F02.B2, F02.C2)
- dementia without behavioral disturbance (F02.80, F02.A0, F02.B0, F02.C0)
- mild neurocognitive disorder due to known physiological condition (F06.7-)
Also applies, from Viral and prion infections of the central nervous system (A80-A89)
These notes sit on A80-A89 and apply to every code under it, including A81.
Official coding guidelines
From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.
Rules for coding infections and parasitic diseases, including HIV, organism and drug resistance codes, sepsis and septic shock, MRSA, Zika, and COVID-19.
- Human Immunodeficiency Virus (HIV) Infections (page 19)
- Infectious agents as the cause of diseases classified to other chapters (page 22)
- Infections resistant to antibiotics (page 22)
- Sepsis, Severe Sepsis, and Septic Shock (page 23)
- Methicillin Resistant Staphylococcus aureus (MRSA) Conditions (page 27)
- Zika virus infections (page 28)
- Coronavirus infections (page 28)
All codes under A81
A81 can't be used on a claim. Pick a billable code below; grey headings group them.
- A81.0Creutzfeldt-Jakob disease
- A81.00Creutzfeldt-Jakob disease, unspecified
- A81.01Variant Creutzfeldt-Jakob disease
- A81.09Other Creutzfeldt-Jakob disease
- A81.1Subacute sclerosing panencephalitis
- A81.2Progressive multifocal leukoencephalopathy
- A81.8Other atypical virus infections of central nervous system
- A81.81Kuru
- A81.82Gerstmann-Straussler-Scheinker syndrome
- A81.83Fatal familial insomnia
- A81.89Other atypical virus infections of central nervous system
- A81.9Atypical virus infection of central nervous system, unspecified
A81 MS-DRGs
As the principal diagnosis, the billable codes under A81 group to these 7 MS-DRGs (v44.0). Which one applies depends on procedures performed, secondary diagnoses (CC/MCC), and the patient's age and discharge status.
- DRG 056 Degenerative Nervous System Disorders with MCC (10 of 10 codes)
- DRG 057 Degenerative Nervous System Disorders without MCC (10 of 10 codes)
- DRG 974 HIV with Major Related Condition with MCC (5 of 10 codes)
- DRG 975 HIV with Major Related Condition with CC (5 of 10 codes)
- DRG 976 HIV with Major Related Condition without CC/MCC (5 of 10 codes)
- DRG 791 Prematurity with Major Problems (1 of 10 codes)
- DRG 793 Full Term Neonate with Major Problems (1 of 10 codes)
About the condition
Plain-language background from MedlinePlus (National Library of Medicine), not coding guidance.
Neurologic Diseases
The brain, spinal cord, and nerves make up the nervous system. Together they control all the workings of the body. When something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. You can also have problems with your memory, senses, or mood.
Read more about neurologic diseases on MedlinePlusViral Infections
Viruses are very tiny germs. They are made of genetic material (either DNA or RNA) inside of a protein coating. There are a huge number of viruses on earth. Only a small number of them can infect humans. Those viruses can infect our cells, which may cause disease. Some of the diseases that viruses can cause include the common cold, the flu, COVID-19, and HIV.
Read more about viral infections on MedlinePlusCode history
Valid since FY2016, when ICD-10-CM took effect on October 1, 2015. No changes since.
