C21.2

Billable

ChapterC00–D49

Ranksubcategory

Official Description

Malignant neoplasm of cloacogenic zone

Metadata & Insights

•2026 ICD-10-CM Edition - Effective October 1, 2025.
•Billable/specific code (valid for reimbursement).
•Chapter 2: Neoplasms (C00-D49).

General instructions are available for the parent sections:

View C15-C26 Notes View C21 Notes

Clinical Hierarchy

CH2Neoplasms (C00-D49)

C15-C26Malignant neoplasms of digestive organs (C15-C26)

C21Malignant neoplasm of anus and anal canal

C21.2Malignant neoplasm of cloacogenic zone

Applicable Ancestor Context

The following parent sections contain instructions or notes that apply to C21.2:

categoryC21

Malignant neoplasm of anus and anal canal

View context instructions

blockC15-C26

Malignant neoplasms of digestive organs (C15-C26)

View context instructions

Alphabetic Index Mentions

These are Diagnosis Index lookup paths that route to C21.2. Use them as entry terms for search, then confirm final coding instructions in the Tabular List and notes above.

3 raw paths

Carcinoma (malignant)1 unique routes

cloacogenic

unspecified site→C21.2

Neoplasm, neoplastic2 unique routes

anus, anal

cloacogenic zone→C21.2

MS-DRG Classification

2026 v43.1

This code is grouped within the following Diagnosis Related Group(s) for clinical reimbursement:

DRG 374

Digestive Malignancy with MCC

DRG 375

Digestive Malignancy with CC

DRG 376

Digestive Malignancy without CC/MCC

Cross Reference

Find Procedures (ICD-10-PCS)

Find surgical and procedural codes related to Malignant neoplasm of cloacogenic zone.

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