K52.21

Billable

ChapterK00–K95

Ranksubcategory

Official Description

Food protein-induced enterocolitis syndrome

Metadata & Insights

•2026 ICD-10-CM Edition - Effective October 1, 2025.
•Billable/specific code (valid for reimbursement).
•Chapter 11: Diseases of the Digestive System (K00-K95).

Instructional Notes

Includes

FPIES

Use Additional Code

code for hypovolemic shock, if present (R57.1)

General instructions are available for the parent sections:

View CH11 Notes View K50-K52 Notes View K52.2 Notes

Clinical Hierarchy

CH11Diseases of the digestive system (K00-K95)

K50-K52Noninfective enteritis and colitis (K50-K52)

K52Other and unspecified noninfective gastroenteritis and colitis

K52.2Allergic and dietetic gastroenteritis and colitis

K52.21Food protein-induced enterocolitis syndrome

Applicable Ancestor Context

The following parent sections contain instructions or notes that apply to K52.21:

subcategoryK52.2

Allergic and dietetic gastroenteritis and colitis

View context instructions

blockK50-K52

Noninfective enteritis and colitis (K50-K52)

View context instructions

chapterCH11

Diseases of the digestive system (K00-K95)

View context instructions

Alphabetic Index Mentions

These are Diagnosis Index lookup paths that route to K52.21. Use them as entry terms for search, then confirm final coding instructions in the Tabular List and notes above.

7 raw paths

Allergy, allergic (reaction) (to)1 unique routes

milk protein

enterocolitis syndrome→K52.21

Colitis (acute) (catarrhal) (chronic) (noninfective) (hemorrhagic)1 unique routes

allergic

with

food protein-induced enterocolitis syndrome→K52.21

Enteritis (acute) (diarrheal) (hemorrhagic) (noninfective)2 unique routes

allergic(2 variants)

with(2 variants)

food protein-induced enterocolitis syndrome→K52.21

FPIES→K52.21

FPIES (food protein-induced enterocolitis syndrome)1 unique routes

Direct index entry→K52.21

Gastroenteritis (acute) (chronic) (noninfectious)1 unique routes

allergic

with

food protein-induced enterocolitis syndrome→K52.21

Syndrome1 unique routes

food protein-induced enterocolitis (FPIES)→K52.21

MS-DRG Classification

2026 v43.1

This code is grouped within the following Diagnosis Related Group(s) for clinical reimbursement:

DRG 391

Esophagitis, Gastroenteritis and Miscellaneous Digestive Disorders with MCC

DRG 392

Esophagitis, Gastroenteritis and Miscellaneous Digestive Disorders without MCC

Cross Reference

Find Procedures (ICD-10-PCS)

Find surgical and procedural codes related to Food protein-induced enterocolitis syndrome.

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